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Coadministration of encorafenib with sensitive CYP3A4 substrates may possibly result in elevated toxicity or lowered efficacy of these agents.Stiripentol is really a CYP3A4 inhibitor and inducer. Check CYP3A4 substrates coadministered with stiripentol for enhanced or decreased effects. CYP3A4 substrates may well have to have dosage adjustment.fedra